Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Description Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the. Sertraline is a medication that increases the amount of serotonin hormone in your brain. It treats depression, anxiety and other mental health conditions. ZOLOFT may be administered either continuously (every day throughout the menstrual cycle) or intermittently (only during the luteal phase of the menstrual cycle, i.e., starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [11] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [12] Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Find out how Zoloft is used to treat anxiety, its effectiveness, dosage, side effects, and when it may be the right option for you. What is Zoloft? Zoloft is the brand name for sertraline, an antidepressant that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It's used to treat a list of mental health conditions, including anxiety and depression, by increasing serotonin levels in your brain. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.